The foundation of chemical engineering was set with mathematical models guided by principles of thermodynamics, transport phenomena and reaction engineering. We believe that biological engineering can too benefit from mathematical models that capture biological complexity in a way fit for analysis and design
In our lab we focus on the development of new antibiotic technologies. There is a pressing need to develop such technologies because of the increase in bacteria that are resistant to our antibiotics.
We develop mathematical models to explain and then engineer and test these antibiotic technologies in a wet lab. Our research efforts integrate biophysical computations and synthetic biology techniques for characterizing and engineering biomolecular systems. From molecules, such as antimicrobial peptides, to gene regulatory networks, such as novel bio-logical AND gates, we are developing model-driven designs that are experimentally realizable.
- 2015 AIChE Division 15c Plenary
- 2010 Charles Bowers Teaching Award, University of Minnesota
- 2009 AIChE CAST Outstanding Young Researcher Award
- J Borrero, Y Chen, GM Dunny, YN Kaznessis " Modified lactic acid bacteria detect and inhibit multi-resistant enterococci ", ACS Synthetic Biology, 2014
- Smadbeck P, Kaznessis YN, "A Closure Scheme for Chemical Master Equations", Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35): 14261-5 10.1073/pnas.1306481110
- Bolintineanu, D; Sayyed-Ahmad A; Davis HT; Kaznessis YN "Poisson-Nernst-Planck Models of Nonequilibrium Ion Electrodiffusion through a Protegrin Transmembrane Pore", PLoS Computational Biology, 2009, 5(1): e1000277.
- Hill, A, J. Tomshine, E. Wedding, V. Sotiropoulos, Y. Kaznessis, "SynBioSS: the Synthetic Biology Modeling Suite", Bioinformatics, 2008, 24(21):2551-2553.