Joseph Zasadzinski

Joseph Zasadzinski

Contact Information
  • California Institute of Technology, BS 1980
  • Ph.D., Chemical Engineering, University of Minnesota, 1985

Research Areas

Research Interests

My research interests center on visualization of molecular and supramolecular ordering in complex fluids, interfaces and biomaterials. Visualizing an ordered fluid requires the ultimate in combined microscopy techniques such as fluorescence and Brewster angle optical microscopy, transmission electron microscopy, scanning tunneling microscopy, and atomic force microscopy. My lab is one of the few in the world that combines state-of-the-art equipment and expertise in all types of microscopy. Research is organized along two broad lines: developing new experimental techniques to make complex fluids and biomaterials compatible with high-resolution microscopy, and using these techniques to create and characterize new biologically inspired materials. We use our technology to explore the relationships between the physics, chemistry and physiology of diseases including cancer, respiratory distress, and multiple sclerosis.


  • 2009, Fellow of the American Physical Society
  • 2004, American Chemical Society Award in Colloid Science
  • 2001, Professeur Invit', University of Bordeaux and the Centre de Recherche Paul Pascal
  • 2000, Fellow of the American Association for the Advancement of Science
  • 1993, Burton Award of the Microscopy Society of America for Best Microscopist under the age of 35
  • 1986, Presidential Young Investigator Award - NSF

Selected Publications

  • Active Microrheology of Aging Protein Films (with P. Dhar, Y. Cao, T. Fischer) Physical Review Letters, 104, Article Number 016001 (2010)
  • Helical Nanofilament Phases,(with E. E. Hough, H.T. Jung, D. Kruerke, M.S. Heberl, M. Nakata, C.D. Jones, D.Chen,G. Heppke, J. Rabe, W. Stocker, E. Korblova, D.A. Walba, M.A. Glaser and N.A. Clark), Science, 325, 456-460 (2009)
  • Rediscovering the Schulze-Hardy Rule in Competitive Adsorption of Surfactant to an Air-Water Interface, (with P.C. Stenger, S.G. Isbell, D. St. Hillaire), Langmuir, 25, 10045-10050 (2009)
  • Laser Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates (with G. Braun, G. Wu, D. Missirlis, M. Tirrell, N. Reich) ACS Nano, 3, 2007-2015 (2009)
  • An X-ray Diffraction and Reflectivity Validation of the Depletion Attraction in the Competitive Adsorption of Lung Surfactant and Albumin (with P.C. Stenger, G. Wu, C.E. Miller, E.Y. Chi, S.L. Frey, K.Y.C. Lee, J. Majewski, K. Kjaer) Biophysical Journal, 97, 777-786 (2009)
  • Interaction Forces and Adhesion of Supported Myelin Lipd Bilayers Modulated by Myelin Basic Protein, (with Y.J. Min, K. Kristiansen, J. Boggs, C. Husted, J.N. Israelachvilli) PHAS, 106, 3154-3159 (2009)
  • Remotely Triggered Liposome Release by Near Infrared Light Absorption via Gold Nanoshells (with G. Wu, A. Mikhailovsky, H.A.Khant, C. Fu, W. Chiu) JACS, 130, 8175-8177 (2008)

Contact Information

Department of Chemical Engineering and Materials Science

421 Washington Ave. SE, Minneapolis, MN 55455-0132

P: 612-625-1313 | F: 612-626-7246

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