The research currently underway in the group centers around questions in polymer physics and microfluidic/nanofluidic technologies. On the polymer side, we are particularly interested in understanding the dynamics of DNA in confined systems, which allows us to simultaneously investigate the basic physical properties of semiflexible polymers while advancing genomics applications. In this area, we use a combination of experimental tools (fluorescence microscopy and nanofabrication), simulations (Brownian dynamics and Monte Carlo) and theory. There is a growing interest in the group on the thermodynamics of block polymers, largely in collaboration with Frank Bates, taking advantage of self-consistent field theory to study the formation of complex phases. On the microfluidics side, we have been working closely with Dan Frisbie on the development of new biosensors based on printed electronics and DNA aptamers. We are also using microchemostats developed in the group to study gene expression and the dynamics of bacterial DNA as part of a larger HFSP-funded collaboration.
- AES Electrophoresis Society Mid-Career Award, 2014
- Allan P. Colburn Award of the AIChE, 2012
- Guillermo E. Borja Award, 2012
- Camille Dreyfus Teacher-Scholar Award, 2010
- DARPA Young Faculty Award, 2009
- Packard Fellowship in Science and Engineering, 2007
- NSF CAREER Award, 2007
- Camille and Henry Dreyfus Foundation New Faculty Award, 2006
- Human Frontier Science Program Career Development Award, 2006
- Scott P. White, Srinand Sreevatsan, C. Daniel Frisbie and Kevin D. Dorfman, Rapid, selective, label-free aptameric capture and detection of ricin using a printed floating gate transistor. ACS Sensors 1, 1213-1216 (2016).
- Akash Arora, Jian Qin, David C. Morse, Kris T. Delaney, Glenn H. Fredrickson, Frank S. Bates, and Kevin D. Dorfman, Broadly accessible self-consistent field theory for block polymer materials discovery. Macromolecules 49, 4675-4690 (2016).
- Pranav Agrawal, Nilesh P. Ingle, William S. Boyle, Emily Ward, Jakub Tolar, Kevin D. Dorfman and Theresa Reineke, Fast, efficient, and gentle transfection of human adherent cells in suspension. ACS Applied Materials & Interfaces 8 8870-8874 (2016).
- Siddharth Chanpuriya, Kyugtae Kim, Jingwen Zhang, Sangwoo Lee, Akash Arora, Kevin D. Dorfman, Kris T. Delaney, Glenn H. Fredrickson and Frank S. Bates, Cornucopia of nanoscale ordered phases in sphere-forming tetrablock terpolymers. ACS Nano 10, 4961-4972 (2016).
- Aashish Jain, Julian Sheats, Jeffrey G. Reifenberger, Han Cao and Kevin D. Dorfman, Modeling the relaxation of internal DNA segments during genome mapping in nanochannels. Biomicrofluidics 10, 0544117 (2016).
- Xiaolan Li and Kevin D. Dorfman, Effect of excluded volume on the force-extension of wormlike chains in slit confinement. Journal of Chemical Physics 144, 104902 (2016).
- Scott P. White, Kevin D. Dorfman and C. Daniel Frisbie, Operating and sensing mechanism of electrolyte-gated transistors with floating gates: Building a platform for amplified biodetection. J. Phys. Chem. C 120, 108-117 (2016).
- John W. McAllister, Peter W. Schmidt, Kevin D. Dorfman, Timothy P. Lodge and Frank S. Bates, Thermodynamics of aqueous methylcellulose solutions. Macromolecules 48, 7205-7215 (2015).
- Julian Sheats, Jeffery G. Reifenberger, Han Cao and Kevin D. Dorfman, Measurements of DNA barcode labels in nanochannels from time-series data. Biomicrofluidics 9, 064119 (2015).
- Damini Gupta, Jeremy J. Miller, Abhiram Muralidhar, Sara Mahshid, Walter Reisner and Kevin D. Dorfman, Experimental evidence of weak excluded volume effects for nanochannel confined DNA. ACS MacroLetters 4, 759-763 (2015).